This has good synergy with Guppy's Tail as well, since it increases the number of Chests appearing, which become Red Chests with the Left Hand.
The Left Hand Trinket can increase the likelihood of becoming Guppy, since it turns all future Chests into Red Chests, which can contain Guppy items. 
For instance, if Isaac has The Dice and found Guppy's Paw in the Devil Room, he can pick it up, then switch back to the Dice to reroll it for another Devil Room item, potentially being another Guppy item.
Therefore, the latter can be a method to acquire another Guppy item. Having picked the items up at some point is the only thing that matters, so even though Guppy's Head and Paw are both activated items, Isaac will still transform even if he picked up one of them earlier and left it behind, or rerolled it with The Dice. Transforming into Guppy unlocks Guppy's Hair Ball. Once transformed, Isaac will gain flight and an enhanced version of The Mulligan, which always spawns Attack Flies when he or his familiars' tears strike an enemy. All of the Guppy items except Dead Cat are exclusive to Wrath of the Lamb. All of them can potentially be found in the Devil Room, Curse Room and Red Chests. Dead Cat, Guppy's Tail, Guppy's Head or Guppy's Paw have a unique feature: Isaac can permanently transform himself into Guppy when he collects any three of them in a single playthrough.
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